“I turned 40 on [the Charlie’s Angels sequel]. After that, there was so much focus on my external self; no one knew where to put me. But I do feel like things have changed. We see so many more interesting roles for women who are 40 to 50 — what I would call “young women.” The Substance is harsh in how it tackles the entertainment industry, its judgments and its beauty standards. But it’s also throwing this idea that a woman’s desirability ends with her fertility in Hollywood’s face.”