Over the course of 15 seasons and 327 episodes, Sam and Dean Winchester (Jared Padalecki and Jensen Ackles) saved people, hunted things (the family business), saved the world more than a few times, didn’t always succeed in saving each other, lost countless loved ones along the way, and stepped out of the box for several could-only-happen-on-Supernatural installments.

This year marks the 20th anniversary of the WB-turned-CW series that is just as beloved now — maybe even more so, with fans still streaming hours of it and attending conventions around the world — as it was when it first premiered on September 13, 2005. In honor of that, we’ve ranked our 20 favorite episodes of the series below.

For a deep-dive into 20 years of Supernatural, from behind-the-scenes scoop to exclusive cast interviews, photos, and fan stories, pick up a copy of TV Guide Magazine’s Supernatural Afterlife: 20th Anniversary Special issue, available on newsstands and for order online at Supernatural.TVGM2025.com.