Not every TV love story gets a happy ending. While we all hope our favorite pairs ride off into the sunset together, sometimes the TV universe wants us to weep.

Over the years, there have been countless devastating love stories that we’ve watched unfold across shows like Grey’s Anatomy, How I Met Your Mother, Lessons in Chemistry, Power, and most recently, We Were Liars. Just because two characters are soulmates doesn’t automatically guarantee their endgame status.